Anti-Nmda Encephalitiis Care Report

In: Science

Submitted By elstooge
Words 2283
Pages 10
Anti-NMDA Encephalitis: A Novel Presentation of Schizophrenia

Stephen A Belz B Pharm MPS
The Prince Charles Hospital Pharmacy Department
Rode Road, Chermside QLD 4032
ABSTRACT
Background: It has been suggested that the modulation of dopamine is not the complete story when it comes to the pathophysiology of schizophrenia. Multiple other neurotransmitters have been linked to the condition such as NMDA & Serotonin. N-methyl D-asparate (NMDA) modulation has been used with success for a number of other conditions such as pain control and Alzheimer’s disease. Due to the high incidence of relapse and treatment failure of current therapies, it is vitally important that medical science looks further into the modulation of the other neurotransmitters involved.
Aim: To report one case that illustrates a novel presentation of treatment resistant schizophrenia, that through extensive investigation produced a diagnosis of anti-NMDA antibody encephalitis.
Clinical details and outcome: The patient had experienced extensive treatment for schizophrenia over at least 5 documented years at a number of institutions & hospitals with varying degrees of success. The patient’s presentation to TPCH resulted in the detection of Anti-NMDA antibodies leading to the diagnosis. Treatments used included immunomodulators and antipsychotics.
Conclusions: After a prolonged admission, the patient was discharged back to her family substantially improved and is receiving maintenance immunoglobulin doses every 3 months. The antipsychotic medications have been weaned over a prolonged period to ensure no relapse of symptoms.
Abstract Word count: 206
Case report word count: 1601

INTRODUCTION
Schizophrenia is a chronic neuropsychiatric disorder that has a worldwide prevalence of 1% and doesn’t vary significantly between geographical regions1. The disorder is characterised by…...

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